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The weapons available to the player get increasingly advanced and powerful as the enemies become increasingly difficult and numerous. The player can have two weapons equipped at any time, such as a shovel and an assault rifle. As well as the available mutations being randomly generated, the levels themselves are procedurally generated, with every playthrough having a unique set of levels for the user to complete.The player starts with the basic revolver, but they may upgrade by taking weapons from red chests and collect more ammunition by opening yellow chests.
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Upon mutating 10 times the player can choose a character-specific 'ultra-mutation'.
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The game has a leveling system, where the player gains experience in the form of radiation pellets, or 'rads', dropped by enemies, that allow them to get different mutations and choose what would benefit the character the most out of a selection of four, randomly selected mutations.
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